Coenzyme Q10 is an attractive ingredient for many cosmetic applications. Coenzyme Q10 prevents very effective oxidative stress in human skin cells. It protects from chronological and photoaging of dermal fi broplasts. It reduces the negative effects of photoaging which is shown by reducing the depth of wrinkles. Coenzyme Q10 (CoQ10) is present in almost all viable cells in the body. The primary functions of this nutraceutical include its actions as an antioxidant, a membrane stabilizer and as a cofactor in metabolic pathways, especially in the production of adenosine triphosphate (ATP), the “energy currency” of the body. In addition, CoQ10 offers a number of benefits associated with human health and wellbeing. Free radicals Chemically, free radicals can be defined as an atom or molecule with an unpaired electron. In the process of trying to balance itself electronically, by gaining or losing an electron, the free radical causes oxidative damage on a cellular level. CoQ10 has the unique property of being able to accept or donate an electron without itself becoming a free radical. By doing this CoQ10 can help neutralize free radicals and the oxidative damage they cause. This is significant since many body cells and tissues are damaged by an excess of free radicals. Over time, unquenched free radicals can cause progressive cell and tissue damage. Mitochondrial health Mitochondrial insufficiency is one of the main causes of the age-related decline of cellular energy production (bioenergetic decline). In addition to being the principal source of energy for all cells, mitochondria are also the primary site of free radical production. Research has found CoQ10 deficiency in some patients with mitochondrial insufficiency. Supplementation with CoQ10 has been demonstrated to reduce symptoms in some patients with genetic and acquired disorders of mitochondrial insufficiency